Thiazine 100 Injection - 50ml

Xylazine sedative, analgesic and muscle relaxant

COMPOSITION
Contains: XYLAZINE 100 mg/mL (as hydrochloride)

ACTIONS
Xylazine is a non-narcotic sedative, analgesic and muscle relaxant with a rapid therapeutic response expected within 1 - 5 minutes of intravenous injection. Sedation is maintained for 1 - 2 hours, while significant levels of analgesia last 15 - 30 minutes. The duration and depth of analgesia and sedation achieved are dependent on dose and the temperament of the animal.

INDICATIONS
THIAZINE 100 has many clinical applications, including:
Radiography: To calm animals and reduce movement during radiography.
Diagnostic Procedures: During more painful &/or intricate procedures, such as endoscopy, catheterisation, peritoneal tap or ophthalmic, rectal or vaginal examinations.
Minor Surgical Procedures: To assist with procedures such as bandage changes, cast application and removal, and minor suturing and surgical procedures under local anaesthesia.
Anaesthesia: In combination with Ketamine to induce full surgical anaesthesia. Post-anaesthesia to smooth difficult recoveries.
Spasmodic Colic: THIAZINE 100 may be used as an analgesic/ sedative in spasmodic (hypermotility) colic, however it is contraindicated in cases of obstructive colic or ileus as xylazine will further reduce gut motility.

DOSAGE AND ADMINISTRATION
Any unused portion of product should be discarded 3 months after first broaching the vial.
Horses: Vary dosage schedule according to circumstances and depth and duration of sedation required. Intravenous administration usually gives a more rapid onset of effect, but the duration is shorter than with intramuscular administration.
Xylazine may be used alone or combined with other sedatives, analgesics and anaesthetics to produce the desired effect from mild sedation to heavy sedation to (in combination with ketamine) full surgical anaesthesia.

Mild sedation:
Intravenous (slow): 0.25 - 0.5 mL per 100 kg bodyweight (0.25 - 0.5 mg per kg).

Heavy sedation:
Intravenous (slow): 1.1 mL per 100 kg bodyweight (1.1 mg per kg).

Intramuscular: 2.2 mL per 100 kg bodyweight (2.2 mg per kg).

Spasmodic Colic:
Intravenous (slow): 0.5 mL per 100 kg bodyweight (0.5 mg per kg).

Thiazine 100 may be used as a sedative/ analgesic in spasmodic (hypermotility) colic. However, it is contraindicated in cases of obstructive colic or ileus as xylazine will further reduce gut motility. In early stages of presentation of colic, it may be difficult to differentiate between spasmodic colic and one that will progress to obstructive colic.
Therefore, considerable care should be taken in diagnosis and alternative analgesia used if diagnosis is in doubt. This dose will provide analgesia for about 20 minutes. Other alpha - 2 adrenoceptor agonists may provide more powerful and longer lasting sedation and analgesic effects. In cases of moderate to severe spasmodic colic, profound analgesia can be achieved by combining butorphanol with xylazine (0.5mg per kg).

PRESENTATION
50 mL glass multidose vial for injection

STORAGE
Store below 25°C (Air Conditioning). Protect from light.
Any unused portion of product should be discarded 3 months after first broaching the vial.

WARNINGS
Not recommended for use in animals with cardiovascular or cardiac disease, shock, hypotension or hypertension, respiratory depression, renal or hepatic disease. It is normal for xylazine to produce cardiopulmonary depression (decreased heart and respiratory rates and cardiac output), particularly with intravenous administration. These effects are transient, but may be significant in cases of cardiopulmonary disease or shock.
Xylazine is contraindicated for intra-arterial administration, obstructive colic or ileus, mares in last trimester of pregnancy and/or concurrent administration with adrenaline. Animals which appear sedated may react suddenly and unpredictably to noise and painful stimuli. Exercise due caution when handling xylazine-sedated horses as hypersensitivity to touch around the hindquarters may result in kicking.
Meat Withholding Period (Horses): 28 Days.
If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.