Detomo Vet Injection 10ml

Detomidine sedative, analgesic and muscle relaxant

COMPOSITION
Detomidine Hydrochloride 10 mg/mL

ACTIONS
Detomidine is a non-narcotic sedative, analgesic, and muscle relaxant, with a rapid dose-dependent effect. Sedation may be expected within 1 - 5 minutes following intravenous injection (slightly longer following intramuscular administration). Full analgesic effect is expected 5 - 15 minutes after administration. A period of sedation is maintained for 0.5 - 6 hours, depending on the dose rate given.

INDICATIONS
Detomo Vet can be used in any situation requiring reliable sedation of horses, particularly if analgesia is also required. As a sedative, the dose can be altered to produce reliable variations in depth and duration of sedation. Examples of indications for use include sedation for diagnostic or radiographic procedures; dental procedures; transport and clipping. Although Detomo Vet causes reduced levels of consciousness, horses will remain standing (do not support the horse artificially - it will seek and find its own unsupported balance). Horses sedated with Detomo Vet experience fewer involuntary gross motor movements (e.g. involuntary kicking) than experienced under other non-narcotic sedatives such as Acepromazine or Xylazine.

Radiography: use a low dose of Detomo Vet (see dosage schedule) to aid positioning for x-rays.
Diagnostic Procedures: which may cause discomfort or resentment, such as catheterisation, oral and ophthalmic examinations, rectal and vaginal investigations.
Minor Surgery: including application and removal of casts, dressing changes, minor suturing, surgical procedures with local anaesthetic. Use alone or in conjunction with narcotics such as butorphanol.
Pre-anaesthesia: Detomo Vet may be used as a reliable pre-anaesthetic sedative. At recommended dose rates Detomo Vet will produce a potentiation of the effects of CNS depressant barbiturate anaesthetic agents. The dosage of such compounds should be correspondingly reduced and administered to effect. Post anaesthetic excitement has not been observed using Detomo Vet as the pre-anaesthetic agent.
Colic: Detomo Vet is an effective analgesic sedative in the horse, with full analgesic occurring 5 - 15 minutes after administration. Like other alpha-2 adrenoreceptor agonists, some smooth muscle relaxation may occur when using Detomo Vet. Therefore it is useful when cases of spasmodic colic have been diagnosed by the veterinarian. Do not use when colic is originating from literal or functional intestinal obstructions or from paralytic ileus.

Withhold feed until the effects of the drug wear off. Failure of relief, or very short relief of pain following administration is often an indication of the need for surgical intervention in colics.

PRESENTATION
10 mL sterile glass multidose vial for injection.

STORAGE
Store below 25°C (Air Conditioning). Protect from light.

NOTES
Other effects of Detomo Vet administration include:

• Piloerection, sweating, diuresis and occasional slight tremors, particularly at higher doses.
• Decrease in heart rate and increase in arterial blood pressure at the recommended dose levels. Recovery to pre-administration rate and pressure occurs at approximately the same time as the clinical effect wears off.
• Slight and transitory arrhythmias, and secondary A-V and S-A blocks may occur.
• Reduced involuntary gastrointestinal movements.
• Respiratory rate is depressed and then increases; respiratory pauses may occur.
• CNS depression causes reduced consciousness but animals will remain standing.
• Overdose may be treated with atropine or specific alpha-2 antagonist.

WARNINGS
When sedating horses in a crush or stables with Detomo Vet, take care that the head is not allowed to drop over the crush front or stable door, as obstruction of the trachea and subsequent hypoxia may result in hypoxic collapse.
Detomo Vet is not recommended for use in pregnant mares. Use with caution in stallions during the breeding season as penile relaxation may occur. Because of possible interactions, it is recommended that intravenous potentiated sulphonamides should not be administered to horses sedated with Detomo Vet.
Feed should be withheld until the effects of the drug have worn off.


Meat Witholding Period: NOT TO BE USED in horses that may be slaughtered for human consumption.