Pentosan Equine Injection 100ml
CEVA |
E00220B

Pentosan Equine Injection 100ml

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Description
Concentrated anti-inflammatory and stimulant of cartilage synthesis, repair and protection (250 mg/mL)

COMPOSITION
Contains: Pentosan Polysulfate Sodium 250 mg/mL

ACTIONS
Pentosan Polysulfate Sodium (PPS)
  • A semi-synthetic polysaccharide polymer based on an extract of the Beechwood plant
  • A sulfated heparinoid with reduced anti-coagulant effects and enhanced anti-inflammatory, fibrinolytic, and tissue trophic effects
  • Directly stimulates joint repair, rather than simply masking pain like many joint treatments

PENTOSAN EQUINE ACTIVELY REVERSES EXISTING JOINT DAMAGE AND PROTECTS AGAINST FURTHER DEGRADATION VIA 5 DIRECT ACTIONS:
  1. Improves Cartilage Quality - Chondrocytes are stimulated to produce more proteoglycans to build and repair cartilage matrix.
  3. Improves Joint Fluid Quality - Synovial fibroblasts are stimulated to produce increased amounts of high molecular weight hyaluronic acid resulting in more normally-viscous joint fluid for optimal lubrication and shock-absorption.
  5. Inhibits Destructive Enzymes - The release of many degradative enzymes which damage cartilage and cause peri-articular inflammation are inhibited. In addition, release of an enzyme which inhibits these degradative enzymes is stimulated.
  7. Provides Anti-Inflammatory Activity - Inflammation is reduced via a powerful inhibitory effect on all mediators of the arachidonic acid cascade and lysosomal catabolic enzymes. Leukocyte migration into joints is also reduced.
  9. Increases Blood Supply to Joints - Strong fibrinolytic action promotes dissolution of thrombi and fibrin deposits, and mobilisation of lipids and cholesterol in synovial tissues and subchondral blood vessels. This improves blood exchange to maximise healing ability and promote normal intraosseus pressure.


INDICATIONS
An aid in the treatment of non-infectious, inflammatory joint disease in horses. In particular :
  1. Osteoarthritis - especially with involvement of multiple joints
  2. Osteochondrosis dissecans
  3. Traumatic joint and peri-articular inflammation


PRESENTATION
100 mL sterile glass vial of Pentosan Polysulfate Sodium 250 mg/mL. Each vial provides one IM dose (1500 mg) for a 500 kg horse at the recommended dose rate of 3 mg/kg.

STORAGE
Store below 25°C (Air Conditioning). Do not freeze. Protect from light.

WARNINGS
Use in horses with clotting defects, traumatic haemorrhage, infection, renal or hepatic failure, or within 48 hours of surgery. Meat Withholding Period (Horses): 28 Days.
Additional Information
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