Pamlin Injection 20ml

COMPOSITION
Diazepam 5 mg/mL.

ACTIONS
Diazepam is a member of the benzodiazepine group of centrally acting drugs. The benzodiazepines are responsible for muscle relaxant, sedative, anxiolytic and anticonvulsant effects at clinical dose rates. Ataxia results from higher dose rates.
It is believed the benzodiazepines act on the reticular formation (specifically, the reticular facilitatory system) to significantly reduce transmission of polysynaptic reflexes. On administration, such blockade has been shown to be immediate and of up to four hours duration.
Work with labelled benzodiapezines has demonstrated the presence of discrete high affinity benzodiazepine receptive sites in the mammalian brain. These receptors are widely distributed throughout the grey matter and have been postulated to be responsible for the anxiolytic and anticonvulsant actions of the benzodiazepines.

INDICATIONS
Horses. An anticonvulsant in foals and a preanaesthetic to xylazine-ketamine anaesthesia in horses.
Dogs. For use as an anticonvulsant and a preanaesthetic.

PRESENTATION
20 mL sterile multidose vial

STORAGE
Store below 30°C (room temperature). Protect from light. To avoid microbial contamination, use the contents of the vial within 24 hours of initial broaching and discard any unused portion.

CONTRAINDICATIONS
Do not use in pregnant animals.

WARNINGS
Pamlin should not be stored in plastic syringes as diazepam is denatured by contact with plastic for more than a few minutes.

PRECAUTIONS
Avoid intra-arterial administration. Avoid injection into small veins as phlebitis and thrombosis may result. Pamlin should be given by slow intravenous injection as propylene glycol contained in the formulation may cause bradycardia and fatal cardiac arrest if administration is too rapid.
Withholding Periods Meat Horses: 28 days.