Halo IV Injection

Hyaluronic Acid injection to reduce inflammation and repair and protect joints

COMPOSITION
Contains: 6 mL SODIUM HYALURONATE 10 mg/mL

ACTIONS
Sodium hyaluronate, the sodium salt of hyaluronic acid (HA), is a non-sulphated glycosaminoglycan (GAG) which is present in many body tissues including connective tissue and skin and in synovial (joint) fluid in very high concentrations. HA provides visco-elastic properties to joint fluid and functions as a lubricant.
In joint disease, inflammation leads to the accumulation of inflammatory cells and degradative enzymes in the joint fluid which break down HA.
The loss of HA results in lowered viscosity of the joint fluid and further influx of inflammatory cells, leading to further cartilage damage and worsening joint disease. Supplementation of sodium hyaluronate helps to replace HA lost as a result of joint disease and thereby restores lubrication of the joint, reduces inflammatory infiltrates and minimises ongoing damage.

INDICATIONS
To aid in the management of non-infectious inflammatory joint disease in horses that may be associated with early equine degenerative joint disease.

HALO INJECTION is easy to administer and eliminates the usual risks of intra-articular injection which include joint damage, septic arthritis and drug-induced joint reaction. The product allows for treatment of multiple joint problems throughout the body with each intravenous injection. Due to the highly vascular nature of the equine synovial membrane it is possible that intrvenous administration provides the synoviocytes with more exposure to exogenous hyaluronic acid than intra-articular administration.

PRESENTATION
HALO INJECTION pack contains: 6 vials of 6 mL Sodium Hyaluronate 10 mg/mL

STORAGE
Store below 25°C (Air Conditioning).
This product does not contain an antimicrobial preservative. Any solution remaining following withdrawal of the required volume should be discarded.

NOTES
Where massive vascularisation of the synovia exists, intra-venous administration may promote wider delivery of the exogenous sodium hyaluronate to synoviocytes. Intra-venous administration may also be preferable for animals with chronic and/or multiple problems.
Combination of sodium hyaluronate with corticosteroids for the treatment of joint disease may produce a more rapid response than either product administered alone. In addition, sodium hyaluronate may reduce the potential deleterious effects of corticosteroids on joint structures.

WARNINGS
Radiographic examination should be undertaken prior to administration to rule out joint fractures or advanced degenerative joint disease.
When administering to competition horses, ensure that the regulations of relevant authorities are observed.
Meat Witholding Period: NIL